Gupta RK, Batra VV, Singh D, Sharma MC, Kumar V. Neurol India. The lack of strict diagnostic criteria to clearly indicate such mesenchymal neoplasms is the main reason which generated the risk of terming the same lesion under different names or, conversely, of collecting different types under the same term. Spindle cell oncocytomas are considered to arise from folliculostellate cells, which are sustentacular cells of the adenohypophysis. eCollection 2018. Accordingly, differential diagnosis between the benign spindle cell lesions and the potentially aggressive tumors is mandatory to avoid overdiagnosis and overtreatment. Mesenchymal tumours represent one of the most challenging field of diagnostic pathology and refinement of classification schemes plays a key role in improving the quality of pathologic diagnosis and, as a consequence, of therapeutic options. Shintaku M, Yamamoto Y, Kono F, Kitai T, Tsuji W, Yotsumoto F, Kushima R. Virchows Arch. Whereas granular cell tumors were negative for bcl-2 and CD56, pituicytomas and spindle cell oncocytomas showed variable positivity. How to Classify the Pituitary Neuroendocrine Tumors (PitNET)s in 2020. J Clin Med. A case report with review of literature. COVID-19 is an emerging, rapidly evolving situation. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. Pituitary spindle cell oncocytoma presented as pituitary apoplexy. Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle cell lipoma, myofibroblastoma, solitary fibrous tumor, myogenic stromal tumor). Clear cell tumors should be distinguished from other primary or metastatic pulmonary tumors, especially those with prominent clear cells, such as clear cell carcinoid in the lung, metastatic renal cell carcinoma, metastatic melanoma, granular cell tumors, oncocytoma, and acinic cell carcinoma. eCollection 2019 Oct. Transgend Health. 2018 Sep-Oct;66(5):1413-1418. doi: 10.4103/0028-3886.241353. Occasional larger polygonal cells. Diffuse TTF-1 expression in nontumorous pituicytes, pituicytomas, spindle cell oncocytomas, and granular cell tumors indicates a common pituicyte lineage. Oncocytic and granular cell neoplasms of the central nervous system and pituitary gland. Intermediate (locally aggressive) Atypical lipomatous tumour / well differentiated liposarcoma. HHS Diagnoses were reclassified acc … Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma. Epub 2016 Jul 25. Spindle cells are of mesenchymal origin, and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels. This category includes spindle cell carcinoma, pleomorphic adenoma, and malignant melanoma. Syndrome of Inappropriate Antidiuresis in a Young Adult-Searching for the Causative Needle in the Proverbial Haystack. A rare case of pituicytoma presenting with severe Cushing disease: A case report and review of literature. The cells were variable in size but uniformly spindle- There was evidence of some necrosis and much hemorrhage. All tumors were classified as low‐grade well‐differentiated spindle cell STS. eCollection 2019 Jun. In spindle cell carcinoma, the most sensitive and reliable epithelial markers to be used for demonstration of the epithelial phenotype are keratin (AE1/AE3) and EMA. Pathologica. Some of them such as the inflammatory pseudotumor and the postoperative spindle cell nodule are reactive and clinically benign although they may be responsible for significant symptoms. Well differentiated neuroendocrine tumor Large cell neuroendocrine carcinoma Small cell neuroendocrine carcinoma Paraganglioma Awareness of this entity including its unique morphologic and immunophenotypic features as well as its interchangeable kinase gene fusions is crucial for correct classification and … 1 A small subset of both LGFMS and hyalinizing spindle tumour … Please enable it to take advantage of the complete set of features! We propose the terminology "oncocytic pituicytomas" and "granular cell pituicytomas" to refine the classification of these lesions.  |  Figarella-Branger D, Dufour H, Fernandez C, Bouvier-Labit C, Grisoli F, Pellissier JF. doi: 10.1093/jscr/rjz179. Surg Pathol Clin. Epub 2015 Apr 18. 2015 Jul;32(3):221-7. doi: 10.1007/s10014-015-0219-3. This classification is based on the predominance of spindle cells in the histopathology of the lesions of the oral cavity. Kidney Int Rep. 2019 Nov 6;5(2):231-234. doi: 10.1016/j.ekir.2019.10.010. CLASSIFICATION OF LUNG TUMOURS  Primary  Epithelial –Adeno carcinoma -Squamous cell carcinoma -Adenosquamous carcinoma -Neuro endocrine tumors -Large cell carcinoma -Salivary gland tumours -Sarcomatoid carcinomas  Mesenchymal • Pulmonary hamartoma • Chondroma • PEComatous tumors  Lymphohistiocytic tumors  Ectopic origin  Metastatic The name is descriptive of its microscopic appearance with features of both mesenchymal and neuroendocrine differentiation. Utility of STAT6 and 13q14 deletion in the classification of the benign spindle cell stromal tumors of the breast. Please enable it to take advantage of the complete set of features! Hypothalamic Endocrine Tumors: An Update. We investigated 7 spindle cell oncocytomas, 4 pituicytomas, and 3 granular cell tumors for their genetic (BRAF(V600E) mutation and BRAF-KIAA fusion), immunohistochemical … NIH Trouillas J, Jaffrain-Rea ML, Vasiljevic A, Raverot G, Roncaroli F, Villa C. Cancers (Basel). 17 These are bulky intraluminal masses that most often develop in the mid esophagus of middle-aged to elderly men (80%).  |  Diagn Pathol. The awareness of the diversity of morphological and immunophenotypical features of BSCTs of the mammary stroma, including uncommon variants, is helpful to avoid confusion with other monomorphic bland-looking benign and malignant spindle cell tumors and tumor-like lesions of the breast. Clipboard, Search History, and several other advanced features are temporarily unavailable. Malignant Dedifferentiated liposarcoma Myxoid liposarcoma Pleomorphic liposarcoma Liposarcoma, not otherwise specified. This site needs JavaScript to work properly. doi: 10.1097/MD.0000000000017772. This classification will be useful for the cytopathologists/oral pathologists who are dealing with oral neoplasms. •Refresh and broaden your knowledge of spindle cell lesions •Help you to establish a histology based approach for classification of spindle cell tumors •Learn distinctive features of select spindle cell tumors for accurate identification 2019 Nov;98(44):e17772. The infrequent exposure of pathologists to soft tissue spindle cell neoplasms coupled with overlapping histologic patterns can often make diagnosis challenging. SMA+, ALK+ (about 55%, especially childhood visceral tumors) ALK gene rearrangements. Spindle cell oncocytomas are considered to arise from folliculostellate cells, which are sustentacular cells of the adenohypophysis. On histologic examination (Figs. Spindle cell carcinoma, also termed carcinosarcoma, pseudosarcoma, polypoid carcinoma, sarcomatoid carcinoma, and spindle cell variant of squamous cell carcinoma, is a rare type of malignant tumor that often grows as an exophytic polypoid lesion (see also Chapter 20). Bland-looking spindle cell lesions of the breast comprise a heterogeneous group of tumor-like and tumor entities, ranging from reactive to low-grade malignant neoplasms with metastatic potential 1.(. The recent publication of the new WHO classification of Soft Tissue Tumours and Bone represents a major step toward improved standardization of diagnosis. 3-5 The category of “mixed-type liposarcoma” was removed for the 2013 classification. This site needs JavaScript to work properly. 2002 Mar;440(3):249-60. doi: 10.1007/s00428-001-0572-y. 2018 Jan 1;3(1):1-9. doi: 10.1089/trgh.2017.0026. Spindle cell sarcoma stage 4 – This is a severe stage wherein the tumor has spread to other parts of the body including the lymph nodes. Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and phylloides tumor, are typically large, fast-growing masses that form from the periductal stromal cells of the breast.They account for less than 1% of all breast neoplasms Low-grade myofibroblastic sarcoma arising in fibroadenoma of the breast-A case report. Acta Neuropathol. GFAP, vimentin, S100, galectin-3, EMA, and CD68 were variably positive in the majority of the 3 tumor groups. AE1/AE3 and EMA, on the spindle cell component, can be useful in the differential diagnosis … 2016;2016:1714382. doi: 10.1155/2016/1714382. Epithelial tumors include tumors of epithelial tissue origin. Granular cell tumors of the pituitary gland are thought to arise from granular pituicytes. Thus, this rare subheading of lung neoplasms includes pleomorphic carcinoma, spindle cell carcinoma, giant cell … Spindle cells are mesenchymal in origin and are spindle cell tumors are usually described as a spindle cell variant of another common malignancy, such as squamous cell carcinoma, melanoma, or sarcomas. Spindle cells in fascicles or myxoid fasciitis-like patterns. Magro G, Bisceglia M, Michal M, Eusebi V. Virchows Arch. • Benign spindle cell tumor with adipocytic component (spin- dle cell lipoma-like tumor) • Solitary fibrous tumor Myofibroblastic tumors • Myofibroblastoma • Leiomyoma? NLM Cases << Back to overview Case ID: 171. Myofibroblastoma of the Breast: Literature Review and Case Report. The lack of strict diagnostic criteria to clearly indicate such mesenchymal neoplasms is the main reason which generated the risk of terming the same lesion … 2016 Mar 25;11:33. doi: 10.1186/s13000-016-0480-8. It can arise in any part of the body but is most common in the limbs (arms and legs). Median overall ST and DFI were not reached because <50% of the dogs died of disease‐related events.  |  Spindle cell / pleomorphic lipoma Hibernoma. Epub 2002 Jan 4. 2018 Nov;81:55-64. doi: 10.1016/j.humpath.2018.06.015. Epub 2018 Jun 27. Further complicating the classification is the lack of established criteria for the number of sections that must be examined to make a diagnosis of “pure” spindle cell thymoma (World Health Organization [WHO] type A)… There is no definite known cause for this type of tumour, but it can sometimes occur as a result of previous radiotherapy treatment. Publication date: 11 Nov, 2020. General Changes The current classification no longer includes mixed-type liposarcoma. Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM. All tumors had nuclear positivity for TTF-1 and were negative for CAM5.2, chromogranin-A, and NF. Marked inflammation, plasma cells prominent especially in areas of sclerosis. Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when examined under a microscope. Their actual incidence is difficult to calculate because different series of thymomas have reported different incidences of this particular histologic type. Focal sclerosis without spindle cells. Although such neoplasms exhibit morphological and immunophenotypical heterogeneity, they actually represent variations of the same tumor entity, likely arising from the uncommitted vimentin+/CD34+ fibroblasts of the mammary stroma, capable of multidirectional mesenchymal differentiation.  |  NLM Stromal tumors of the lower female genital tract: histogenetic, morphological and immunohistochemical similarities with the "benign spindle cell tumors of the mammary stroma". TTF-1-positive oncocytic sellar tumor with follicle formation/ependymal differentiation: non-adenomatous tumor capable of two different interpretations as a pituicytoma or a spindle cell oncocytoma. Tumor Classification. Our case expands the molecular genetic spectrum of the distinctive group of spindle cell tumors with CD34/S100+ immunophenotype, supporting the important role of various kinases as drivers of oncogenesis. Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. Introduction. NCI CPTC Antibody Characterization Program. 2017 Oct;471(4):531-535. doi: 10.1007/s00428-017-2179-y. 2007;203(11):827-9. doi: 10.1016/j.prp.2007.08.005. Spindle cell thymomas represent one of the most unusual histologic types in the general spectrum of thymic epithelial neoplasms, namely thymomas. Clipboard, Search History, and several other advanced features are temporarily unavailable. USA.gov. Pituicytomas are neoplasms that arise from pituicytes, which are specialized glia of the posterior pituitary. USA.gov. Spindle cell malignancies of the breast were identified as International Classification of Diseases for Oncology, Third Edition, code 8004/3 for malignant tumor, spindle cell type, 8032/3 for SpCC, and 8801/3 for spindle cell sarcoma. (1, 2, 3, 4, 5) Image 1: A primary tumor categorized as intermediate grade spindle cell sarcoma. F > M eCollection 2020 Feb. Li X, Liu Y, Miao Y, Wang J, Wang L, Wang EH. HHS Pathol Res Pract. [5] Retiform hemangioendothelioma (also known as a "Hobnail hemangioendothelioma" [3] ) is a low-grade angiosarcoma , first described in 1994, presenting as a slow-growing exophytic mass, dermal plaque, … Leiomyosarcoma. Recent data suggest that, whereas pituicytes and all 3 tumor types are positive for TTF-1, folliculostellate cells are negative for TTF-1. Epub 2017 Jun 26.  |  Magro G, Angelico G, Righi A, Benini S, Salvatorelli L, Palazzo J. Hum Pathol. Monophasic spindle cell lesions of the breast can be divided morphologically into inflammatory/reactive (fibrous scar, desmoid fibromatosis and nodular fasciitis), low-grade (myofibroblastoma, fibromatosis-like metaplastic carcinoma, neural and lipomatous tumors), and high-grade (monophasic spindle cell metaplastic carcinoma, metaplastic carcinoma with heterologous components, sarcomas and … Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle cell lipoma, myofibroblastoma, solitary fibrous tumor, myogenic stromal tumor). Medicine (Baltimore). To cover the entire spectrum of such lesions, the term "benign spindle cell tumors (BSCTs) of the mammary stroma" is advocated. ISUP Home Pathology Imagebase Classification of renal tumors. Hagel C, Buslei R, Buchfelder M, Fahlbusch R, Bergmann M, Giese A, Flitsch J, Lüdecke DK, Glatzel M, Saeger W. Pituitary. 2017 Apr;20(2):211-217. doi: 10.1007/s11102-016-0762-x. Gaetano M, Giuseppe A, Saveria S, Rosalia R, Alberto R, Enrico O. Pol J Pathol. Recent data suggest that, whereas pituicytes and all 3 tumor types are positive for TTF-1, folliculostellate cells are negative for TTF-1. The tumor cells were spindle and histiocytoid in shape, with clear to pale eosinophilic cytoplasm, a low nuclear to cytoplasmic ratio, small central nucleoli, and inconspicuous mitotic activity without any necrosis (Fig 1f). Spindle cell neoplasms are dened as neoplasms that consist of spindle-shaped cells in the histopathology. Spindle cell tumors are a heterogeneous group of skin neoplasms. Yoshimoto T, Takahashi-Fujigasaki J, Inoshita N, Fukuhara N, Nishioka H, Yamada S. Brain Tumor Pathol. NIH Mitotic index counts ranged from 0 to 3.1/10 HP fields, with a median of 0.31 and a mean of 0.42. Based on the morphologic and immunohistochemical findings, the following histotypes were identified: (i) tumors (10/19 cases) with the characteristic morphology of myofibroblastoma and stained with vimentin, CD34, desmin, and α-smooth muscle actin; (ii) fibroblastic benign spindle cell tumors (5/19 cases) composed of fibroblast-like cells stained only with vimentin and CD34; (iii) tumors (2/19 cases) … : 599 These tumors were reclassified by Dr. Weiss in 1996 as "spindle cell hemangioma", rather than hemangioendothelioma, due to the excellent prognosis observed in a group of 78 patients. Classification of BSCT of the mammary stroma Fibroblastic tumors • Benign spindle cell tumor N.O.S. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Cytogenetic studies of spindle cell tumour show two cell lines containing balanced translocation between chromosomes 7 and 16. The tumors generally begin in layers of connective tissue such as that under the skin, between muscles, and surrounding organs, and will generally start as a small lump with inflammation that grows. Adult cystic nephroma Mixed epithelial and stromal tumor Neuroendocrine tumors. Is spindle cell oncocytoma a true entity or a variant of pituicytoma? Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. A case report of a mammary myofibroblastoma in a male and literature review of radiologic and pathologic features of breast myofibroblastoma. Stata 12.1 software was used to produce descriptive statistics regarding age, sex, race, disease grade, disease stage, and tumor, node, metastasis classification … Olig2 was only positive in 1 pituicytoma. 2018 Mar;11(1):91-121. doi: 10.1016/j.path.2017.09.005. COVID-19 is an emerging, rapidly evolving situation. At first the lump will be self-contained as the tumor exists in its stage 1 state, and will not necessarily expand beyond its encapsulated form. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Cases previously diagnosed as mixed-type … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. These tumors appeared to have originated from the intermuscular fascia. 2002 Sep;104(3):313-9. doi: 10.1007/s00401-002-0557-1. BSCTs can be subtyped into four main groups by light microscopy (LM) and immunocytochemistry (ICC): fibroblastic, myofibroblastic, fibrohistiocytic, and mixed forms.  |  All tumors were negative with the IDH1-R132H mutation-specific antibody, and none had evidence of BRAF alterations (BRAF(V600E) mutation and BRAF-KIAA fusion). Chondrolipoma of the breast as a rare variant of myofibroblastoma: an immunohistochemical study of two cases. J Surg Case Rep. 2019 Jun 14;2019(6):rjz179. These cells, with more of a spindle shape made up >75% of the tumor. Epub 2002 Jun 19. Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. We reviewed all nonodontogenic spindle cell neoplasms seen between 1982 and 2002 (86,162 total accessions). Epidermal, melanocytic, muscle, or fibrohistiocytic tumors may each present as spindle-shaped cells … The ultrastructural variants of pituicytes are reflected in these 3 morphologic variants of tumors arising from these cells. Spindle cell proliferations of diverse types which vary greatly in their behavior may occur in the urinary bladder. Akrami M, Ebrahimian S, Safaei A, Tabrizi Z, Ebrahimian S. Clin Case Rep. 2019 Sep 3;7(10):1968-1971. doi: 10.1002/ccr3.2413. However, it may develop cancerous proc… Case Rep Oncol Med. We investigated 7 spindle cell oncocytomas, 4 pituicytomas, and 3 granular cell tumors for their genetic (BRAF(V600E) mutation and BRAF-KIAA fusion), immunohistochemical (GFAP, vimentin, S100 protein, olig2, IDH1-R132H, NF, galectin-3, chromogranin-A, CD56, EMA, CAM5.2, CD68, TTF-1, and bcl-2), and ultrastructural features to refine their classification.